Corticobasal Degeneration

Corticobasal degeneration (CBG) is a progressive neurological disease that affects several regions of the brain, including the cortex, frontotemporal regions, and parts of the basal ganglia.  The cause of corticobasal degeneration is unknown.  Patients usually begin to experience symptoms after 60 years of age.  Symptoms include poor coordination, rigidity, slowness of movement, shakiness, and difficulty with speech.  Initially, symptoms appear on one side of the body and gradually spread to the other side.  Behavioral and memory problems are also common.

Corticobasal degeneration is diagnosed by physical and neurological examination, laboratory evaluations, electroencephalography (EEG), and computed tomography (CT) or magnetic resonance imaging (MRI).

No treatment is available to arrest or slow the progression of the disease, although some medications are effective in offering symptomatic relief.  Physical therapy is useful for maintaining range of motion, decreasing pain, and maintaining mobility.  Occupational therapists can provide recommendations for adaptive equipment to support activities of daily living.