Yongchang Chang, MD, PhD

Skip Navigation



Advanced Search



Yongchang Chang, MD, PhD


Yongchang Chang, MD, PhD

Principal Investigator, Laboratory of Ion Channel Biophysics

Dr. Yongchang Chang is an Associate Professor in the Division of Neurobiology at Barrow Neurological Institute. He received his medical degree in 1982 from Sun Yat-sen University of Medical Sciences, Guangzhou, China, and his PhD in Physiology and Biophysics in 1998 from the University of Alabama at Birmingham.

Dr. Chang has over 18 years of experience studying the structure-function relationship of ligand-gated ion channels. He has published 34 peer-reviewed research papers, 4 review papers, and 4 book chapters. Dr. Chang has a current NIH R01 grant to study dynamic structural basis for the mechanism of activation and antagonism of GABAC receptors (PI) and a current NIH U19 grant to develop nicotinic ligands as new antidepressants (co-project leader). He has also successfully completed NIH-supported research to investigate the role of GABA receptor-mediated excitation in the epilepsy of human hypothalamic hamartoma (co-investigator) and an Arizona Biomedical Research Commission-supported research to study GABA receptor structure-function relationship.

Selected Publications

  1. Zhang J, Xue F, Whiteaker P, Li C, Wu W, Shen B, Huang Y, Lukas RJ, Chang Y. Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem. Jul 15 2011;286(28):25331-25340.

  2. Li C, Wen A, Shen B, Lu J, Huang Y, Chang Y. FastCloning: a highly simplified, purification-free, sequence- and ligation-independent PCR cloning method. BMC Biotechnol. 2011;11:92.

  3. Dash B, Chang Y, Lukas RJ. Reporter mutation studies show that nicotinic acetylcholine receptor (nAChR) alpha5 Subunits and/or variants modulate function of alpha6*-nAChR. J Biol Chem. Nov 4 2011;286(44):37905-37918.

  4. Zhang J, Xue F, Chang Y. Agonist- and antagonist-induced conformational changes of loop F and their contributions to the rho1 GABA receptor function. J Physiol. Jan 15 2009;587(Pt 1):139-153.

  5. Liu Q, Huang Y, Xue F, Simard A, DeChon J, Li G, Zhang J, Lucero L, Wang M, Sierks M, Hu G, Chang Y, Lukas RJ, Wu J. A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci. Jan 28 2009;29(4):918-929.

  6. Zhang J, Xue F, Chang Y. Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors. Mol Pharmacol. Oct 2008;74(4):941-951.

  7. Wu J, DeChon J, Xue F, Li G, Ellsworth K, Gao M, Liu Q, Yang K, Zheng C, He P, Tu J, Kim do Y, Rho JM, Rekate H, Kerrigan JF, Chang Y. GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas. Exp Neurol. Oct 2008;213(2):397-404.

  8. Chen Y, Reilly K, Chang Y. Evolutionarily conserved allosteric network in the Cys loop family of ligand-gated ion channels revealed by statistical covariance analyses. J Biol Chem. Jun 30 2006;281(26):18184-18192.

  9. Sedelnikova A, Smith CD, Zakharkin SO, Davis D, Weiss DS, Chang Y. Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model. J Biol Chem. Jan 14 2005;280(2):1535-1542.

  10. Chang Y, Weiss DS. Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism. Nat Neurosci. Nov 2002;5(11):1163-1168.
Bottom of Navigation
 

Legal & Privacy Notices

 

Payment Assistance

Contact Us

Hospital Accreditation

© 2014 Dignity Health

Barrow Neurological Institute
350 W. Thomas Road
Phoenix, AZ 85013
(602) 406-3000