Andrej A. Romanovsky, MD, PhD

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Andrej A. Romanovsky, MD, PhD


Andrej A. Romanovsky, MD, PhD
Professor
Director, Systemic Inflammation Laboratory (FeverLab)

Andrej A. Romanovsky, MD, PhD, is an integrative physiologist studying body temperature regulation and systemic inflammation. Originally from St. Petersburg, Russia, Dr. Romanovsky was granted his MD with Distinction by the Ivan Pavlov Medical University (St. Petersburg) in 1984. He completed his pathophysiology residency in 1986 at the Pavlov Institute of Experimental Medicine of the Russian Academy of Medical Sciences in St. Petersburg.

In 1989, he received a PhD in physiology from the Institute of Physiology of the National Academy of Sciences (Minsk, Belarus) and at the age of 29 became the youngest Senior Scientist in the history of that institute. Following postdoctoral training at the University of Tennessee Medical School in Memphis (1991–1994), Dr. Romanovsky accepted the position of Associate Scientist and Director of the Thermoregulation Laboratory at the Legacy Health System in Portland, Oregon (1994–2000). He joined St. Joseph's Hospital and Medical Center in Phoenix in December of 1999 to direct the Systemic Inflammation Laboratory (FeverLab), a part of the Trauma Research program. He also serves as a faculty member of the Graduate Program in Neuroscience and the Graduate Program in Molecular and Cellular Biology at Arizona State University and holds an Adjunct Professor appointment at the ASU School of Life Sciences. Dr. Romanovsky is a member of the Scientific Advisory Board of the Ivan Pavlov Medical University, his alma mater.

Dr. Romanovsky has published more than 100 articles in peer-reviewed scientific journals, including Pharmacological Reviews, Nature Neuroscience, PLoS Biology, Progress in Lipid Research, Blood, Clinical Infectious Diseases, Frontiers in Neuroendocrinology, and Journal of Neuroscience. He has served as an academic editor, associate editor, invited or guest editor, and board member for fourteen professional journals. He has served on study sections and reviewed grant applications for the National Institutes of Health, the National Science Foundation, the Medical Research Council (UK), the Canadian Institutes of Health Research, the Swedish Research Council, the Dutch Research Council, the National Research Foundation (South Africa), the National Council of Romania, the Polish National Science Center, the government of Hong Kong, and other agencies. Dr. Romanovsky’s research has been funded by the National Institutes of Health, the State of Arizona, and a number of pharmaceutical companies and foundations. 

 

Selected Publications


  1. Rance NE, Dacks PA, Mittelman-Smith MA, Romanovsky AA, Krajewski-Hall SJ. Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes. Front Neuroendocrinol. 2013 Aug;34(3):211-227.

  2. Saper CB, Romanovsky AA, Scammell TE. Neural circuitry engaged by prostaglandins during the sickness syndrome. Nat Neurosci. 2012 Jul 26;15(8):1088-95.

  3. Almeida MC, Hew-Butler T, Soriano RN, Rao S, Wang W, Wang J, Tamayo N, Oliveira DL, Nucci TB, Aryal P, Garami A, Bautista D, Gavva NR, Romanovsky AA. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012;32(6):2086-2099.

  4. Garami A, Pakai E, Oliveira DL, Steiner AA, Wanner SP, Almeida MC, Lesnikov VA, Gavva NR, Romanovsky AA. Thermoregulatory phenotype of the trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci. 2011;31(5):1721-1733.

  5. Garami A, Shimansky YP, Pakai E, Oliveira DL, Gavva NR, Romanovsky AA. Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia. J Neurosci. 2010;30(4):1435-1440.

  6. Romanovsky AA, Almeida MC, Garami A, Steiner AA, Norman MH, Morrison SF, Nakamura K, Burmeister JJ, Nucci TB. The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev. 2009;61(3):228-261.

  7. Gavva NR, Treanor JJ, Garami A, Fang L, Surapaneni S, Akrami A, Alvarez F, Bak A, Darling M, Gore A, Jang GR, Kesslak JP, Ni L, Norman MH, Palluconi G, Rose MJ, Salfi M, Tan E, Romanovsky AA, Banfield C, Davar G. Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain. 2008;136(1-2):202-210.

  8. Steiner AA, Turek VF, Almeida MC, Burmeister JJ, Oliveira DL, Roberts JL, Bannon AW, Norman MH, Louis JC, Treanor JJ, Gavva NR, Romanovsky AA. Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci. 2007;27(28):7459-7468.

  9. Steiner AA, Romanovsky AA. Leptin: at the crossroads of energy balance and systemic inflammation. Prog Lipid Res. 2007;46(2):89-107.

  10. Steiner AA, Ivanov AI, Serrats J, Hosokawa H, Phayre AN, Robbins JR, Roberts JL, Kobayashi S, Matsumura K, Sawchenko PE, Romanovsky AA. Cellular and molecular bases of the initiation of fever. PLoS Biol. 2006;4(9):e284.

  11. Steiner AA, Chakravarty S, Rudaya AY, Herkenham M, Romanovsky AA. Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood. 2006;107(10):4000-4002.

  12. Steiner AA, Dogan MD, Ivanov AI, Patel S, Rudaya AY, Jennings DH, Orchinik M, Pace TW, O'connor KA, Watkins LR, Romanovsky AA. A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia. FASEB J. 2004;18(15):1949-1951.
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