Systemic Inflammation Laboratory

Andrej A. Romanovsky, MD, PhD

Senior Staff Scientist
Director, Systemic Inflammation Laboratory

Biographical Sketch

The Systemic Inflammation Laboratory is a basic research unit of the Trauma Program of St. Joseph's Hospital, a Level-1 Trauma Center. 

The laboratory was created as the Trauma Metabolic Laboratory in 1986. From 1986 to 1999, the laboratory was directed by Malayappa Jeevanandam, PhD. During that time, the laboratory focused on studying the metabolic consequences of trauma disease.

Since December 1999, the laboratory has been headed by Andrej Romanovsky. The new research focus of the laboratory is on the neural basis and molecular mechanisms of the physiological and behavioral manifestations of systemic inflammation. Andrej's primary interest is in studying mechanisms of fever and hypothermia associated with systemic inflammation.

Selected Publications

Almeida MC, Steiner AA, Branco LG, Romanovsky AA. Neural substrate of cold-seeking behavior in endotoxin shock. PLoS ONE 1: e1, 2006. (PDF).

Steiner AA, Ivanov AI, Serrats J, Hosokawa H, Phayre AN, Robbins JR, Roberts JL, Kobayashi S, Matsumura K, Sawchenko PE, Romanovsky AA. Cellular and molecular bases of the initiation of fever. PLoS Biol 4: e284, 2006. (PDF)

This research was originally published in Blood. Steiner AA, Chakravarty S, Rudaya AY, Herkenham M, Romanovsky AA. Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood 107: 4000-4002, 2006. (PDF) © the American Society of Hematology.